APHID: Anomaly Processor in Hardware for Intrusion Detection

The Anomaly Processor in Hardware for Intrusion Detection (APHID) is a step forward in the field of co-processing intrusion detection mechanism. By using small, fast hardware primitives APHID relieves the production CPU from the burden of security processing. These primitives are tightly coupled to the CPU giving them access to critical state information such as the current instruction(s) in execution, the next instruction, registers, and processor state information. By monitoring these hardware elements, APHID is able to determine when an anomalous action occurs within one clock cycle. Upon detection, APHID can force the processor into a corrective state, or a halted state, depending on the required response. APHID primitives also harden the production system against attacks such as Distribute Denial of Service attack and buffer overflow attacks. APHID is designed to be fast and agile, with the ability to create multiple monitors that switch in and out of monitoring with the context switches of the production processor to highly focused coverage over multiple devices and sections of code

Characterisation of community acquired non-typhoidal Salmonella from bacteraemia and diarrhoeal infections in children admitted to hospital in Nairobi, Kenya

BACKGROUND: In sub-Saharan Africa community-acquired non-typhoidal Salmonella (NTS) is a major cause of high morbidity and death among children under 5 years of age especially from resource poor settings. The emergence of multidrug resistance is a major challenge in treatment of life threatening invasive NTS infections in these settings. RESULTS: Overall 170 (51.2%) of children presented with bacteraemia alone, 28 (8.4%) with gastroenteritis and bacteraemia and 134 (40.4%) with gastroenteritis alone. NTS serotypes obtained from all the cases included S. Typhimurium (196; 59%), S. Enteritidis (94; 28.3%) and other serotypes in smaller numbers (42; 12.7%); distribution of these serotypes among cases with bacteremia or gastroenteritis was not significantly different. A significantly higher proportion of younger children (< 3 years of age) and those from the slums presented with invasive NTS compared to older children and those from upper socio-economic groups (p < 0.001). One hundred and forty-seven (44.3%) NTS were resistant to 3 or more antibiotics, and out of these 59% were resistant to ampicillin, chloramphenicol and tetracycline. There was no significant difference in antibiotic resistance between the two serotypes, S. Typhimurium and S. Enteritidis. Ceftriaxone and ciprofloxacin were the only antibiotics tested to which all the NTS were fully susceptible. Using Pulsed Field Gel Electrophoresis (PFGE) there were 3 main patterns of S. Typhimurium and 2 main patterns of S. Enteritidis among cases of bacteraemia and gastroenteritis. CONCLUSION: Serotype distribution, antibiotic susceptibility and PFGE patterns of NTS causing bacteraemia and gastroenteritis did not differ significantly. The high prevalence of NTS strains resistant to most of the commonly used antimicrobials is of major public health concern

MEMPSEP II. -- Forecasting the Properties of Solar Energetic Particle Events using a Multivariate Ensemble Approach

Solar Energetic Particles (SEPs) form a critical component of Space Weather. The complex, intertwined dynamics of SEP sources, acceleration, and transport make their forecasting very challenging. Yet, information about SEP arrival and their properties (e.g., peak flux) is crucial for space exploration on many fronts. We have recently introduced a novel probabilistic ensemble model called the Multivariate Ensemble of Models for Probabilistic Forecast of Solar Energetic Particles (MEMPSEP). Its primary aim is to forecast the occurrence and physical properties of SEPs. The occurrence forecasting, thoroughly discussed in a preceding paper (Chatterjee et al., 2023), is complemented by the work presented here, which focuses on forecasting the physical properties of SEPs. The MEMPSEP model relies on an ensemble of Convolutional Neural Networks, which leverage a multi-variate dataset comprising full-disc magnetogram sequences and numerous derived and in-situ data from various sources. Skill scores demonstrate that MEMPSEP exhibits improved predictions on SEP properties for the test set data with SEP occurrence probability above 50%, compared to those with a probability below 50%. Results present a promising approach to address the challenging task of forecasting SEP physical properties, thus improving our forecasting capabilities and advancing our understanding of the dominant parameters and processes that govern SEP production

University Information Technology Services' Advanced IT Facilities: The least every researcher needs to know

This is an archived document containing instructions for using IU's advanced IT facilities ca. 2003. A version of this document updated in 2011 is available from http://hdl.handle.net/2022/13620. Further versions are forthcoming.This document is designed to be read as a printed document, and designed to permit anyone at all familiar with computers and the Internet to start at the beginning, get a general overview of UITS' advanced IT facilities and what they offer, and then read the detailed portions of the document that are of interest. In many cases, examples are provided, as well as directions on how to download sample files. And in some cases there is information that one is best off really not learning – for example the process of logging into IU's IBM supercomputer the first time involves setup steps that should be followed, keystroke by keystroke, from the directions presented herein, and then promptly forgotten. This document is intended to be a starting point, not a comprehensive guide. As such it should get any reader off to a good start, but then point the reader in the direction of consulting staff and online resources that will permit the reader to get additional help and information as needed. Most of all, this document is provided for the convenience of researchers, who may peruse this information at their leisure. Our hope and expectation is that consultants in UITS will provide extensive help and programming assistance to IU researchers who wish to make use of these excellent IT facilities.The facilities described in this document were made possible in part through funding from Indiana University, the Indiana University Office of the Vice President for Information Technology, the State of Indiana, Shared University Research Grants from IBM, Inc., the National Science Foundation under Grant No. 0116050 and Grant CDA- 9601632, and from the Lilly Endowment through their support of the Indiana Genomics Initiative. The Indiana Genomics Initiative (INGEN) of Indiana University is supported in part by Lilly Endowment Inc

INGEN's advanced IT facilities: The least you need to know

The facilities described in this document were made possible in part through funding from Indiana University, the Indiana University Office of the Vice President for Information Technology, the State of Indiana, Shared University Research Grants from IBM, Inc., and from the Lilly Endowment through their support o f the Indiana Genomics Initiative. The Indiana Genomics Initiative (INGEN) of Indiana University is supported in part by Lilly Endowment Inc

Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function: the Sun Exposure and Vitamin D Supplementation (SEDS) Study

BACKGROUND Adults living in the sunny Australian climate are at high risk of skin cancer, but vitamin D deficiency (defined here as a serum 25-hydroxyvitamin D (25(OH)D) concentration of less than 50 nmol/L) is also common. Vitamin D deficiency may be a risk factor for a range of diseases. However, the optimal strategies to achieve and maintain vitamin D adequacy (sun exposure, vitamin D supplementation or both), and whether sun exposure itself has benefits over and above initiating synthesis of vitamin D, remain unclear. The Sun Exposure and Vitamin D Supplementation (SEDS) Study aims to compare the effectiveness of sun exposure and vitamin D supplementation for the management of vitamin D insufficiency, and to test whether these management strategies differentially affect markers of immune and cardio-metabolic function. METHODS/DESIGN The SEDS Study is a multi-centre, randomised controlled trial of two different daily doses of vitamin D supplementation, and placebo, in conjunction with guidance on two different patterns of sun exposure. Participants recruited from across Australia are aged 18-64 years and have a recent vitamin D test result showing a serum 25(OH)D level of 40-60 nmol/L. DISCUSSION This paper discusses the rationale behind the study design, and considers the challenges but necessity of data collection within a non-institutionalised adult population, in order to address the study aims. We also discuss the challenges of participant recruitment and retention, ongoing engagement of referring medical practitioners and address issues of compliance and participant retention. TRIAL REGISTRATION Australia New Zealand Clinical Trials Registry: ACTRN12613000290796 Registered 14 March 2013

Indiana University's Advanced Cyberinfrastructure

This is an archived document. The most current version may be found at http://pti.iu.edu/ciThe purpose of this document is to introduce researchers to Indiana University’s cyberinfrastructure – to clarify what these facilities make possible, to discuss how to use them and the professional staff available to work with you. The resources described here are complex and varied, among the most advanced in the world. The intended audience is anyone unfamiliar with IU’s cyberinfrastructure

P-rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments

Expression of the Rac-guanine nucleotide exchange factor (RacGEF), P-Rex1 is a key determinant of progression to metastasis in a number of human cancers. In accordance with this proposed role in cancer cell invasion and metastasis, we find that ectopic expression of P-Rex1 in an immortalised human fibroblast cell line is sufficient to drive multiple migratory and invasive phenotypes. The invasive phenotype is greatly enhanced by the presence of a gradient of serum or platelet-derived growth factor, and is dependent upon the expression of functional PDGF receptor β. Consistently, the invasiveness of WM852 melanoma cells, which endogenously express P-Rex1 and PDGFRβ, is opposed by siRNA of either of these proteins. Furthermore, the current model of P-Rex1 activation is advanced through demonstration of P-Rex1 and PDGFRβ as components of the same macromolecular complex. These data suggest that P-Rex1 has an influence on physiological migratory processes, such as invasion of cancer cells, both through effects upon classical Rac1-driven motility and a novel association with RTK signalling complexes

Locomotor hyperactivity in 14-3-3Zeta KO mice is associated with dopamine transporter dysfunction

Dopamine (DA) neurotransmission requires a complex series of enzymatic reactions that are tightly linked to catecholamine exocytosis and receptor interactions on pre- and postsynaptic neurons. Regulation of dopaminergic signalling is primarily achieved through reuptake of extracellular DA by the DA transporter (DAT) on presynaptic neurons. Aberrant regulation of DA signalling, and in particular hyperactivation, has been proposed as a key insult in the presentation of schizophrenia and related neuropsychiatric disorders. We recently identified 14-3-3ζ as an essential component of neurodevelopment and a central risk factor in the schizophrenia protein interaction network. Our analysis of 14-3-3ζ-deficient mice now shows that baseline hyperactivity of knockout (KO) mice is rescued by the antipsychotic drug clozapine. 14-3-3ζ KO mice displayed enhanced locomotor hyperactivity induced by the DA releaser amphetamine. Consistent with 14-3-3ζ having a role in DA signalling, we found increased levels of DA in the striatum of 14-3-3ζ KO mice. Although 14-3-3ζ is proposed to modulate activity of the rate-limiting DA biosynthesis enzyme, tyrosine hydroxylase (TH), we were unable to identify any differences in total TH levels, TH localization or TH activation in 14-3-3ζ KO mice. Rather, our analysis identified significantly reduced levels of DAT in the absence of notable differences in RNA or protein levels of DA receptors D1–D5. Providing insight into the mechanisms by which 14-3-3ζ controls DAT stability, we found a physical association between 14-3-3ζ and DAT by co-immunoprecipitation. Taken together, our results identify a novel role for 14-3-3ζ in DA neurotransmission and provide support to the hyperdopaminergic basis of pathologies associated with schizophrenia and related disorders.H Ramshaw, X Xu, EJ Jaehne, P McCarthy, Z Greenberg, E Saleh, B McClure, J Woodcock, S Kabbara, S Wiszniak, Ting-Yi Wang, C Parish, M van den Buuse, BT Baune, A Lopez and Q Schwar